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This review summarizes the possible mechanisms linking the ECS to GI disorders and describes the most recent advances in the manipulation of the ECS in the treatment of GI diseases.” Derivatives of ? 9 -tetrahydrocannabinol, such as nabilone and dronabinol, activate cannabinoid receptors and have been introduced into the clinic to treat chemotherapy-induced emesis and loss of appetite; however, they may cause many psychotropic side effects. It is being cultivated and used by man for recreational and medicinal purposes from many centuries. Presently, it is known that endocannabinoids has role in pathology of many disorders and they also serve “protective role” in many medical conditions. Sativex (cannabidiol and THC combination) is approved in the UK, Spain and New Zealand to treat spasticity due to multiple sclerosis.
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ICD-9-CM 723.4 is a billable medical code that can be used to indicate a diagnosis on a reimbursement claim, however, 723.4 should only be used for claims with a date of service on or before September 30, 2015.
These effects can increase or decrease the activity of the corresponding drugs and lead to untoward or unexpected adverse events or changes in drug efficacy. 5 Some herbals may be contaminated with toxic substances or the herbal can be toxic alone.
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